特邀學術報告 - 高分辨率單顆粒冷凍電鏡及其在膜蛋白研究中的應用

發布者:群體微生物研究中心發布時間:2019-06-29瀏覽次數:1

特邀學術報告


時間:201973日下午330

地點:資環樓105室(芭田報告廳)

報告人:廖茂富教授

報告題目:高分辨率單顆粒冷凍電鏡及其在膜蛋白研究中的應用

主持人:張煉輝教授

報告人簡介

廖茂富教授1999年在清華大學獲得生物學士學位,2006年在美國紐約愛因斯坦醫學院獲得生物醫學科學博士學位,隨后在國紐約愛因斯坦醫學院和舊金山加州大學從事博士后工作,2014年入職哈佛醫學院細胞生物學系任副教授,2018年起任教授。廖茂富教授主要從事微生物及真核膜蛋白結構的研究,在冷凍電鏡結構生物學領域取得了突破性進展。近幾年,以第一作者身份(或通訊作者身份)發表4Nature論文,Science研究論文2篇,2Cell論文,累計發表SCI論文24篇。

  

報告內容摘要

Cryo-electron microscopy (cryo-EM) is a rapidly advancing research area, and the technique of single-particle cryo-EM is a 'rising star' in structural biology, providing remarkably versatile and powerful tools to study the structure and function of biological macromolecules. Single-particle cryo-EM has achieved near-atomic resolution for biological samples ranging from large icosahedral viruses (~100 MDa) to small proteins (<100 kDa). Compared to more traditional methods such as X-ray crystallography and NMR spectroscopy, cryo-EM demonstrates a number of important advantages, such as small amount of sample required for EM analysis, flexibility in studying different functional states, and computational sorting of mixed conformations.

The Liao laboratory in the Department of Cell Biology at Harvard Medical School focuses on using single-particle cryo-EM to study membrane proteins. We are particularly interested to reveal the mechanisms of how proteins sense, move and convert specific lipid molecules. This will be achieved by obtaining high-resolution structures of lipid-interacting proteins, and by studying the dynamic protein conformations in native membrane environment.

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